Bevacizumab and Combination Chemotherapy in Patients With Lymph Node Positive Breast Cancer
Status:
Completed
Trial end date:
2009-09-01
Target enrollment:
Participant gender:
Summary
This phase II trial is studying how well giving bevacizumab together with combination
chemotherapy works in treating patients who have undergone surgery for breast cancer that has
spread to the lymph nodes. Monoclonal antibodies, such as bevacizumab, can block tumor growth
in different ways. Some block the ability of tumor cells to grow and spread. Others find
tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may
also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in
chemotherapy work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Giving bevacizumab together with more than one
chemotherapy drug (combination chemotherapy), may be a better way to block tumor growth.