Bevacizumab, Hormone Therapy, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Androgens can cause the growth of
prostate cancer cells. Drugs, such as goserelin and bicalutamide, may stop the adrenal glands
from making androgens. Radiation therapy uses high-energy x-rays to kill tumor cells.
Bevacizumab may also make tumor cells more sensitive to radiation therapy. Giving bevacizumab
together with hormone therapy and radiation therapy may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving bevacizumab together with hormone
therapy and radiation therapy works in treating patients with high-risk locally advanced
prostate cancer.