Betadine Bladder Irrigations vs. Standard of Care Prior to Indwelling Catheter Removal

• Status: Terminated
• Trial end date: 2018-10-22
• Target enrollment: 0
• Participant gender: Male

Summary

Over the last decade, there has been great emphasis on reducing the incidence of hospital-acquired infections, including catheter-associated UTI (CAUTI). This study will evaluate the effectiveness of Betadine irrigation solution (2% povidone-iodine) instilled into the bladder immediately prior to indwelling catheter removal to decrease the risk of subsequent bacteriuria, leading to decreased rates of NHSN defined CAUTI.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: William Beaumont Hospitals
• Treatments: Cadexomer iodine; Iodine; Povidone; Povidone-Iodine

Criteria

Inclusion Criteria:

1. Provide written informed consent and the willingness and ability to comply with all aspects of study requirements

2. Male

3. Inpatients ≥ 18 years of age with an indwelling catheter in place for at least 5 days with a plan for removal

Exclusion Criteria:

1. Patients planned for discharge with an indwelling catheter in place

2. Patients unable to report urinary symptoms accurately

3. Patients with hyper-sensitivity or allergic reaction to Betadine, iodine, shellfish or other related compounds

4. Clinical signs or symptoms of urinary tract infection at the time of consent

5. Patients currently being treated for UTI

6. Patients currently taking any antibiotic medication, other than vancomycin, linezolid, daptomycin, clindamycin, or metronidazole.

7. Patients already taking medications known to potentially irritate the bladder, such as, but not limited to, cyclophosphamide, ifosfamide, and other chemotherapeutic agents

8. Patients with history of bladder cancer, pelvic radiation or interstitial cystitis

9. Patients unable to comply with study requirements

10. Any other condition which, per investigators' judgment, may increase patient risk and/or impede the reliability of study data