Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.
Status:
Recruiting
Trial end date:
2026-12-01
Target enrollment:
Participant gender:
Summary
Research has proven that large varices can be treated with beta-blockers (a type of
anti-hypertensive medication) to reduce the pressure in the veins. The management of small
varices is still uncertain. This study aims to discover if beta blockers can be used in this
setting. We hypothesize that beta blockers will reduce the risk of bleeding from small
varices from 20% to 10% over a period of 3 years, resulting in significant cost savings to
the NHS from better patient outcomes.
Phase:
Phase 4
Details
Lead Sponsor:
King's College Hospital NHS Trust
Collaborators:
Brighton and Sussex University Hospitals NHS Trust Cardiff University King's College London