Beta-blockers for Prevention Of Growth Of Small Esophageal Varices In Cirrhosis: An Randomized Controlled Trial (RCT)
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
Background and Aims: The efficacy of portal pressure reduction by beta blockers for the
management of small (≤5 mm) esophageal varices in patients of cirrhosis is not clear. The
present randomized controlled trial aims to address these issues. The investigators also
assessed the utility of serial HVPG measurements in these patients.
Patients and Methods: Consecutive patients with cirrhosis with small varices, with no history
of variceal bleed, were randomized to receive propranolol or placebo. These patients were
further randomized to undergo no HVPG, only baseline HVPG, or serial HVPG measurement.
Propranolol was titrated to reduce heart-rate to 55/min.