Beta-blockade Effects on Memory for Cocaine Craving

• Status: Completed
• Trial end date: 2011-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of South Carolina
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine; Propranolol

Criteria

Inclusion Criteria:

• Current cocaine dependence (within past month)

• Able to provide informed consent

• Use of birth control by female participants (barrier methods, surgical sterilization, IUD, or abstinence)

• Live within 50-mile radius of research site

• Consent to remain abstinent from all drugs of abuse (except nicotine) for 24 hours prior to inpatient admission and follow-up assessment

• Consent to random assignment to propranolol or placebo

Exclusion Criteria:

• Women who are pregnant, nursing or are of childbearing potential and not practicing/using birth control

• Evidence or history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal or neurological disease

• Significant liver impairment

• History of or current psychotic disorder, current severe major depressive disorder, bipolar affective disorder or a severe anxiety disorder

• Currently taking anti-arrhythmic agents, psychostimulants or other agents known to interfere with heart rate and skin conductance monitoring

• Known or suspected hypersensitivity to propranolol

• Individuals taking medications that could adversely interact with the study medication, including, but not limited to albuterol, insulin, or significant inhibitors of CYP2D6

• Individuals with bronchial asthma or chronic obstructive pulmonary disease