Overview

Beta-Cell Function After Near-Normalisation of Blood Glucose

Status:
Completed
Trial end date:
2007-05-01
Target enrollment:
0
Participant gender:
All
Summary
The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Hvidovre University Hospital
Treatments:
Gastric Inhibitory Polypeptide
Glucagon
Glucagon-Like Peptide 1
Criteria
Inclusion Criteria:

- Age 18-70 years

- Type 2 diabetes diagnosed after 30 years of age

- BMI > 25

Exclusion Criteria:

- Severe complications to diabetes

- Abnormal liver and kidney function

- Haemoglobin below the lower limit

- Macroalbuminuria

- Systemic disease

- Pregnancy