Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
Status:
Recruiting
Trial end date:
2025-05-28
Target enrollment:
Participant gender:
Summary
The goal of this randomized controlled trial is to compare letrozole alone versus letrozole
plus levothyroxine for ovulation induction in infertile women with both PCOS and subclinical
hypothyroidism. The main questions it aims to answer are:
Is letrozole plus levothyroxine superior to letrozole alone in achieving ovulation in these
patients? Does combining levothyroxine with letrozole lead to higher pregnancy and live birth
rates compared to letrozole alone?
Participants will be randomized into two groups:
Group 1 will receive letrozole only, starting at 2.5 mg daily from day 3 to 7 of the
menstrual cycle. The dose will be increased up to 7.5 mg if no ovulation occurs, for a
maximum treatment period of 6 months or until pregnancy is achieved.
Group 2 will receive letrozole at the same doses as group 1 plus 25 mcg levothyroxine daily.