Best Regimen for Phenylephrine Administration During Cesarean Section
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
During Cesarean delivery, phenylephrine is used to maintain the patient's blood pressure. Low
blood pressure is the most common side effect of the spinal medication used to anesthetize
the patient prior to the start of surgery. This low blood pressure can also trigger
unpleasant side effects such as nausea, vomiting and low Apgar scores for the baby.
Currently there are 2 methods of phenylephrine administration during Cesarean section. One
method is by intermittent bolus and the other is by continuous infusion. It is ideal to have
a regimen for phenylephrine administration that maintains blood pressure without compromising
cardiac output.
In this study, cardiac output and blood pressure will be measured by transthoracic
bioimpedance, which is a new technique of noninvasive continuous cardiac output monitoring.
The hypothesis of this study is that the continuous infusion of phenylephrine will be equally
effective in maintaining blood pressure as compared to the intermittent injection, and will
induce less hemodynamic changes.
Phase:
Phase 4
Details
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital