Beraprost Sodium and Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Diabetic nephropathy, the leading cause of end-stage renal disease in many countries, is
characterized by high cardiovascular mortality and morbidity even in the early course of the
disease. In addition, cardiovascular complication has been the most common cause of death in
these patients. Thus, early detection and appropriate intervention for this highly common and
critical complication is considered to play an important role in the management of the
disease. In this regard, much interest has been focused on the early markers which can
predict arterial diseases before the clinically apparent cardiovascular diseases. Recently,
glowing evidence suggests that arterial stiffness as assessed by pulse wave velocity (PWV)
may serve as a surrogate marker for future cardiovascular disease. In fact, increased PWV has
been known to be independently associated with diabetic nephropathy in type 2 diabetes.
Beraprost sodium (BPS) is a stable orally active prostacyclin (PGI2) analogue that has a
potent vasodilatory and anti-platelet effect. Also, BPS has been suggested to improve a
micro-vascular circulation through a reduction of red blood cell deformability. In addition,
recent studies have demonstrated that BPS improves endothelial function through an increase
in endothelial nitric oxide synthesis and NO synthase gene transcription. These beneficial
effects of BPS have been known to reduce PWV in patients prone to cardiovascular diseases
such as elderly, hypertension, or a history of cerebral infarction. However, the effect of
BPS on arterial stiffness in patients with diabetic nephropathy remains elusive. Our study
will address the effect of BPS on arterial stiffness by PWV in patients with diabetic
nephropathy.