Benidipine-based Comparison of Angiotensin Receptors, β-blockers, or Thiazide Diuretics in Hypertensive Patients
Status:
Completed
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
A number of major clinical trials have demonstrated the clinical benefits of lowering blood
pressure and have indicated that a majority of patients with hypertension will require more
than one drug to achieve optimal blood pressure control.
There is little data showing which antihypertensive combination best protects patients from
cardiovascular events and which best achieves the target blood pressure with the fewest
adverse events.
The COPE trial is planned to investigate, in patients with hypertension, which combination of
the antihypertensive drugs, angiotensin receptor blockers, β-blockers or thiazide diuretics
in addition to a long-acting calcium antagonist, benidipine hydrochloride, is superior to
achieve the targeted blood pressure and prevent cardiovascular events with the fewest adverse
drug effects.
Phase:
Phase 4
Details
Lead Sponsor:
Seiji Umemoto, M.D., Ph.D.
Collaborators:
Kyowa Hakko Kogyo Co., Ltd. The Japanese Society of Hypertension Yamaguchi University Hospital