Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections

• Status: Completed
• Trial end date: 2005-03-01
• Target enrollment: 0
• Participant gender: All

Summary

In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting. After implementation of a standardized procedure with a single shot dose of Amoxicillin/Clavulanic Acid approximately 30 min. preoperatively the rate of SSI dropped by 80% in spite of procedural risk factors like poor hygiene etc.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Swiss Tropical & Public Health Institute
• Collaborator: Swiss Academy of Medical Sciences (SAMS)
• Treatments: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antibiotics, Antitubercular; Clavulanic Acid; Clavulanic Acids

Criteria

Inclusion Criteria:

• surgical patient

• clean or clean-contaminated surgery

Exclusion Criteria:

• infection

• preoperative antibiotic treatment

• postoperative antibiotic treatment

• open fractures