Benefit of Pharyngeal and Oesophageal pH-impedance of Patients With High Suspicion of Laryngopharyngeal Reflux

• Status: Completed
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Laryngopharyngeal reflux (LPR) is the retrograde movement of gastric contents into the larynx, pharynx and upper aerodigestive tract. The symptoms and manifestations are very changeable and non specific. Pharyngeal and Oesophageal pH-impedance may help to detect these reflux and to identify patients with abnormal LPR.

To compare and describe the results of pharyngeal and oesophageal pH-impedance of patients with high suspicion of laryngopharyngeal reflux, with the results of healthy patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Bordeaux
• Treatments: Esomeprazole

Criteria

Inclusion Criteria:

• age : 18 to 80 years old.

• Written consent

• Laryngopharyngeal symptoms (dysphonia, and/or globus and/or sensation, and/or pharyngeal pain, and/or cough) for 3 months at least.

• No PPI for at least 15 days

• Social security affiliation

Exclusion Criteria:

• Sinusitis or chronic rhinitis (in the previous year)

• Laryngeal trauma, tracheotomy or pharyngolaryngeal surgery

• pregnancy or absence of efficacy contraception

• breast feeding

• history of gastrointestinal pathology, diabetes, neurological condition

• cardio-vascular history requiring the taking of Plavix

• esomeprazole contraindication or intolerance