Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty

• Status: Not yet recruiting
• Trial end date: 2023-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effects of topiramate (TPM) in obese patients with respect to weight loss and pain after total joint replacement surgery

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Treatments: Gabapentin; Topiramate

Criteria

Inclusion Criteria

• Patient will be eligible for the study if they are scheduled for a primary TKA or THA with a BMI >30 and <40 kg/m2, or >40 kg/m2

• Patients refusing bariatric surgery or having had prior bariatric surgery

Exclusion Criteria

• Patients will be ineligible to participate if they have any of the following:

• known topiramate or gabapentin allergy

• history of seizure disorder

• chronic opiate use pre-operatively

• history of nephrolithiasis

• history of acute angle closure glaucoma

• recurrent major depression

• presence or history of suicidal behavior or ideation with intent to act

• current substantial depressive symptoms (Patient Health Questionnaire total score >10), pregnancy

• child-bearing potential and not on contraception

• age <18 years

• major neurocognitive disorder

• metabolic acidosis

• incarcerated status

• bilateral surgery