Belimumab for Prevention of Chronic Graft-versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation
Status:
Recruiting
Trial end date:
2024-03-31
Target enrollment:
Participant gender:
Summary
Given the role of B cells in the pathophysiology of chronic graft versus host disease (GvHD),
the association between elevated BAFF levels post-transplant in abnormal B-cell homeostasis
and chronic GvHD, and the efficacy of belimumab in the inhibition of soluble human B
lymphocyte stimulator protein (BAFF) signaling, these proof-of-principle findings support the
rational for use of belimumab as prophylaxis of chronic GvHD. The investigators propose a
pilot and feasibility study to assess the safety and tolerability, as well as preliminary
efficacy, of belimumab as prophylaxis of chronic GvHD following allogeneic hematopoietic cell
transplantation (alloHCT). The investigators' central hypothesis is that belimumab will be
well tolerated and have a favorable effect on incidence and severity of chronic GvHD.