This study will compare cognitive behavioral therapy with a time-limited motivational
enhancement therapy to which naltrexone (Revia) or placebo medication is added. In this
randomized clinical trial, 160 alcohol-dependent outpatients, after 5 days of abstinence,
will receive one of the two psychosocial therapies and either naltrexone (Revia) or placebo
for a 12-week treatment period. Abstinence rates, alcohol use, and time to alcohol relapse
will be evaluated in all four groups along with measures of alcohol craving, biological
measures of alcohol consumption, drinking consequences, changes in self-confidence for
avoiding alcohol, and medication compliance. All study participants will be assessed for
measures of outcome variables at 3 and 6 months after completing the treatment protocol.
Phase:
Phase 4
Details
Lead Sponsor:
Medical University of South Carolina
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)