Overview Behavioral Effects of Drugs: Inpatient (35) Status: Completed Trial end date: 2019-05-31 Target enrollment: Participant gender: Summary This study will determine the influence of methylphenidate (Metadate®) and duloxetine (Cymbalta®), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine. Phase: Early Phase 1 Details Lead Sponsor: Craig RushCollaborator: National Institute on Drug Abuse (NIDA)Treatments: CocaineDuloxetine HydrochlorideMethylphenidate