Behavior and Naltrexone Treatment for Alcoholics

• Status: Completed
• Trial end date: 2000-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The study's purpose is to improve alcoholism treatment by investigating the combined effectiveness of a psychotherapy (Coping Skills Training and Cue Exposure Treatment - CSTCET) with naltrexone in a randomized clinical trial. Individuals will receive 2 weeks of CSTCET or a control treatment as inpatients followed by 12 consecutive weeks of receiving either naltrexone or placebo as outpatients. Followups at 24, 48, and 72 weeks after treatment is completed.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Treatments: Naltrexone

Criteria

Inclusion Criteria:

• Meets criteria for alcohol dependence.

Exclusion Criteria:

• Current diagnosis of dependence on other substances except nicotine.

• A history of psychosis or current psychotic symptoms.

• Current suicidality, homocidality, or psychiatric symptoms that require additional medication.

• Current use of disulfiram (Antabuse).

• Evidence of significant cerebral, renal, thyroid, or cardiac disease.

• History of opioid abuse in the previous year.

• History of cirrhosis, hepatocellular disease, or elevated bilirubin.

• Females who are pregnant, nursing, or not using a reliable method of birth control.