Bedtime Insulins and Oral Antihyperglycemic Drugs in Type 2 Diabetes
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
The maintenance of nearly normal glycemic levels reduces the risk of diabetic complications,
but is difficult to achieve, despite the administration of escalating doses of oral
antidiabetic drugs, such as metformin, sulfonylureas, and thiazolidinediones. Most patients
eventually require insulin which usually is added when glycemic control with a regimen of
oral antidiabetic agents becomes suboptimal.
The aims of the present study were: 1) To compare the clinical efficacy of insulin glargine
and neutral protamine lispro (NPL) insulin when added to ongoing oral therapy in poorly
controlled type 2 diabetic patients; 2) to find out the possibility to phenotype the patient
who may benefit more by the single treatment.
This an open-label, randomized, parallel, 36-week comparative study was performed between
January 2007 and March 2008 at a single centre.
Phase:
Phase 4
Details
Lead Sponsor:
Second University of Naples University of Campania "Luigi Vanvitelli"