Basmisanil Positron Emission Tomography Study in Japanese Volunteers
Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
This study will evaluate the relationship between basmisanil plasma concentrations and the
occupancy of Gamma-Amino Butyric Acid A (GABAA) receptor subtypes containing an alpha5 (α5)
subunit in healthy Japanese volunteers. Each participant will have two post-screening imaging
sessions. In the first imaging session, participants will have a baseline Positron Emission
Tomography (PET) scan. In the second imaging session, participants will receive a single oral
dose of basmisanil, followed by two on-treatment PET scans at about 4 and 10 hours post-dose.