Balanced Placebo Design With Varenicline: Pharmacological and Expectancy Effects on Medication Adherence
Status:
Completed
Trial end date:
2019-10-29
Target enrollment:
Participant gender:
Summary
The current study will use the double-blind balanced placebo design to examine differences
between expectancies versus the pharmacological effects of varenicline medication
administered for two weeks to cigarette smokers. The double-blind balanced placebo design
includes medication administration (active medication v. placebo) and medication information
(told truth v. deception) resulting in four groups of smokers: (1) told therapeutic dose (TD)
medication + received TD medication; (2) told TD medication + received placebo; (3) told low
dose (LD) medication+ received TD dose medication; (4) told LD medication + received placebo.
Ecological momentary assessments (EMA) in the form of Daily Dairies delivered via smartphone
will assess real-time side effects, withdrawal symptoms, cigarettes smoked, medication use,
and reasons for medication non-adherence.