Overview

BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance

Status:
Terminated
Trial end date:
2017-09-06
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to assess the ability of bone marrow transplantation (BMT) and high-dose post-transplantation cyclophosphamide (PT/Cy) to induce renal allograft tolerance and thus enable discontinuation of immunosuppressive therapy in haploidentical living related donor renal transplant recipients.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborator:
Immune Tolerance Network (ITN)
Treatments:
Acetaminophen
Antilymphocyte Serum
Cyclophosphamide
Diphenhydramine
Fludarabine
Fludarabine phosphate
Lenograstim
Mesna
Methylprednisolone
Methylprednisolone acetate
Methylprednisolone Hemisuccinate
Mycophenolate mofetil
Mycophenolic Acid
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Prednisone
Promethazine
Thymoglobulin