Overview
BIIB057 in Subjects With Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs
Status:
Withdrawn
Withdrawn
Trial end date:
2014-03-01
2014-03-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
Phase II study designed to evaluate the safety and efficacy of BIIB057 in Subjects with Rheumatoid Arthritis who have experienced an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs).Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
BiogenTreatments:
Antirheumatic Agents
Criteria
Inclusion Criteria:- Adult onset RA satisfying 2010 Revised ACR Criteria for the Classification of RA with
a disease history of at least 6 months
- Active RA as defined by: at least 4 swollen joints (based on 28-joint count), at least
4 tender joints (based on 28-joint count), and high-sensitivity CRP (hsCRP) 10mg/L or
greater
- No prior treatment with biologics
- Receiving a DMARD therapy for at least 3 months, using a regimen that has been stable
for at least 28 days prior to screening
Exclusion Criteria:
- History of inflammatory joint disease other than RA
- Abnormal chest X-ray consistent with tuberculosis, malignancy, or infection
- History of malignancy, carcinoma in situ, or high-grade dysplasia
- History of opportunistic infection, infection requiring treatment, serious local
infection, recent fever, active herpes zoster or Epstein-Barr virus, or diagnosis or
family history of Creutzfeldt-Jakob disease.
- Clinically significant cardiac disease
- Treatment with prednisone >10 mg orally daily
- Intra-articular steroid injection within 28 days before screening
- Clinically significant abnormality in hematology or blood chemistry values at
screening