B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The long-range goal of this proposal is to decrease morbidity and mortality related to pulmonary edema and congestive heart failure (CHF) in post-operative patients. The short-range goal is to determine a mechanistic endpoint when therapy for impending heart failure can be initiated and terminated based on B-type natriuretic peptide (BNP) levels. The investigators propose to utilize changing levels of BNP as a surrogate marker for CHF.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Creighton University
• Treatments: Furosemide; Natriuretic Peptide, Brain

Criteria

Inclusion Criteria:

• General Surgery patients with history of coronary artery disease, congestive heart failure, pulmonary hypertension

• Cardiac surgery patients undergoing CABG (coronary artery bypass grafting) and valve replacements

Exclusion Criteria:

1. Recent myocardial infarction (within 3 months).

2. ASA class 4 and more.

3. Emergency surgeries.