The primary objective of the study is to evaluate the efficacy of a booster-free regimen
including DOR/DTG/3TC among HIV-suppressed PLWH with previous virological failure. The key
secondary objectives are i) to determine whether switching to DOR / DTG / 3TC leads to lower
burden of DDI compared to continuing a booster-containing regimen, and ii) to assess changes
in patient perception on treatment acceptability and satisfaction, as well as health-related
quality of life after a switch to booster-free ART.
Qualitative sub-study:
Qualitative objectives will be met using semi-structured interviews. Thirty people (15 from
the intervention arm, 15 from the control arm) will be interviewed twice, at week 0 and week
48. Additional 15 individuals from the observational cohort will be interviewed once.
Interviews will take place following study visits and performed using semi-structured guides.
The guide for the interviews at week 48 will be based on results from analyses of the
interviews conducted at week 0.
Phase:
Phase 4
Details
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Collaborators:
Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland University of Bern