In this project, the investigators propose to test effectiveness of a daily nutraceutical
supplement containing bioactive B vitamins to mitigate optic disc edema in astronauts. The
proposed countermeasure is intended to maximize functioning of the one-carbon metabolic
pathway to provide enough substrate and cofactors to overcome any genetic differences that
may impact the efficiency of enzyme function. By optimizing the pathway, this will 1)
optimize endothelial function by increasing eNOS coupling and nitric oxide synthesis and 2)
optimize collagen firmness and elasticity in the sclera and lamina cribrosa, and 3) minimize
changes in total retinal thickness during and after flight.
The protocol includes assessments of ocular health and function, along with determinants of
vascular endothelial function, advanced glycation end products, and nutritional status and
one carbon biochemistry. These additional measures will be critical for the further
definition of the causes of optic disc edema in some astronauts after long-duration space
flight, and in understanding the effect of the countermeasure. Finally, the supplemented
subjects in this study will be compared against total retinal thickness data from previously
flown astronauts known to have not taken supplements during their missions.
Phase:
Phase 1
Details
Lead Sponsor:
National Aeronautics and Space Administration (NASA)