Overview B-Cell Targeted Carfilzomib Desensitization Status: Recruiting Trial end date: 2021-09-01 Target enrollment: Participant gender: Summary The primary purpose of this study is to provide a preliminary evaluation of the safety and potential efficacy of carfilzomib in reducing HLA antibody levels in highly sensitized kidney transplant candidates. Phase: Phase 1 Details Lead Sponsor: E. Steve WoodleCollaborators: AmgenOnyx PharmaceuticalsTreatments: Rituximab