Azithromycin for Preterm Pre-labor Rupture of Membranes
Status:
Not yet recruiting
Trial end date:
2021-03-01
Target enrollment:
Participant gender:
Summary
The preterm prelabour rupture of membranes is defined as the spontaneous rupture of the fetal
membranes before 37 completed weeks. Preterm prelabour rupture of membranes complicates up to
3% of pregnancies and is associated with 30-40% of preterm births. preterm prelabour rupture
of membranes can result in significant neonatal morbidity and mortality, primarily from
prematurity, sepsis, cord prolapse, and pulmonary hypoplasia. In addition, there are risks
associated with chorioamnionitis and placental abruption The diagnosis of spontaneous rupture
of the membranes is made by maternal history followed by a sterile speculum examination. If
on speculum examination, no amniotic fluid is observed, clinicians should consider performing
an insulin-like growth factor-binding protein-1 or placental alpha microglobulin-1 test of
vaginal fluid to guide further management.
One of the risks associated with preterm prelabour rupture of membranes is ascending
infection leading to chorioamnionitis, and subsequent fetal and neonatal infection.