Azithromycin Treatment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and Tracheostomy
Status:
Terminated
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
Aims of the study
- to evaluate the rate of enteric gram negative bacteria colonization in tracheotomised
COPD patients
- to evaluate the effect of azithromycin long-term treatment on Pseudomonas aeruginosa
colonization and colony counts, and on reduction of the number of
exacerbations/hospitalisations, antibiotic courses and steroid use.
- to evaluate the Quality of Life of patients treated and not treated with azithromycin,
using a validate Italian version of St George questionnaire
- to evaluate the rate of chronic colonization with atypical pathogens
- to evaluate the safety and tolerability of a long-term treatment with azithromycin,
including a survey on possible bacterial antibiotic resistance pattern variations