Azelastine Fluticasone Combination vs. Fluticasone

• Status: Withdrawn
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to see how a combination spray of azelastine and fluticasone (antihistamine and steroid) compares with a steroid nasal spray (fluticasone) alone in allergic rhinitis i.e. does azelastine permit the use of lesser steroid dose (steroid sparing effect) to achieve the same benefit.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Dundee
• Treatments: Azelastine; Fluticasone; Xhance

Criteria

Inclusion Criteria:

• Male of Female aged 18-65 years.

• Persistent allergic rhinitis with or without asthma.

• Atopy to at least one allergen on SPT.

• Ability to give a written informed consent.

• Ability and willingness to comply with the requirements of the protocol.

Exclusion Criteria:

• Recent respiratory tract/sinus infection within the last 2 months. .

• Pregnancy, planned pregnancy or lactation.

• Known or suspected hypersensitivity to any of the IMP's.

• Concomitant use of medicines (prescribed, OTC or herbal) like alpha blockers that may interfere with the trial.

• Nasal Polyposis grade 2+, Deviated nasal septum ≥ 50%

• The use of oral corticosteroids within the last 3 months.