Availability Study of ACTH to Treat Children SRNS/SDNS
Status:
Unknown status
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
Primary nephrotic syndrome(NS) is a common children renal disease.About 20% primary nephrotic
syndrome are steroid-dependent and steroid-resistant.Low serum cortisol is one of the main
relapse reasons.Adrenocorticotropic hormone(ACTH)-induced steroidogenesis improve serum
cortisol and also direct melanocortin receptors(MCRs) mediated protective effect on kidney
cells. To investigate the efficacy and safety of ACTH to treat NS, total 42 children steroid
resistant or steroid dependent NS is enrolling in this multicenter, prospective case series
of prescription based treatment with ACTH for NS.
Phase:
N/A
Details
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine