Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Hydroxychloroquine is a drug that has been used to treat malaria and rheumatism. It is
recently discovered that Hydroxychloroquine increases 'autophagy'. Autophagy is a process
whereby cells eat a part themselves giving them extra energy. Cancer cells use autophagy to
survive chemotherapy or hormonal therapy. Also, cancer cells use autophagy to survive in
areas of a tumor where there is a low oxygen level.
The purpose of this study is to determine whether treatment with the drug Hydroxychloroquine
leads to a decrease of autophagy in breast cancer tissue.