Autonomic Neuropathy, GI Motility, and Inflammation in HIV
Status:
Completed
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to explore a possible link between the autonomic nervous system
and immune function in patients with HIV. Sometimes HIV can cause these nerves to function
abnormally, this is called HIV-associated autonomic neuropathy (HIV-AN). HIV-AN is a
condition that is different from person to person. In some people it causes no symptoms and
is not harmful, in others it may cause symptoms such as dizziness or lightheadedness, nausea,
vomiting, diarrhea, constipation, or problems urinating. Most people with HIV-AN don't know
that they have it. One of the important nerves in the autonomic nervous system is the vagus
nerve. Abnormal function of the vagus nerve may cause stomach and intestinal slowing, which
could lead to an overgrowth of bacteria. The body senses these bacteria and tries to fight
them, leading to inflammation.
In this study the researchers will test whether abnormal function of the vagus nerve in HIV
is associated with stomach slowing and overgrowth of bacteria, and if a drug called
pyridostigmine can help.
Phase:
Early Phase 1
Details
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health (NIH)