Autonomic Nervous System and Chronic Fatigue Syndrome
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
The investigators propose to test the hypothesis that the sympathetic nervous system
contributes to the cardiovascular and inflammatory abnormalities present in the chronic
fatigue syndrome (CFS) and, in particular in the subset of patients characterized by postural
tachycardia syndrome (POTS). CFS and POTS are seen mostly in otherwise normal young women,
and are the cause of significant disability. A substantial proportion of patients referred
for evaluation of POTS met diagnostic criteria for CFS and, conversely, a subset of patients
referred for treatment for CFS have POTS. The investigators hypothesize that sympathetic
activation underlies the pathophysiology of patients in whom CFS and POTS overlap (CFS-P).
Phase:
Phase 1
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center