Autologous Platelet-rich Plasma for Clomiphene Citrate-induced Thin Endometrium
Status:
Completed
Trial end date:
2020-01-01
Target enrollment:
Participant gender:
Summary
This is a prospective self-controlled clinical study. Women with clomiphene Citrate failure
with thin endometrium less than 7 millimeters for at least 3 cycles will be selected (N =
30). Patients will receive 2 ovarian stimulation cycles with Clomiphene citrate (CC) 100 mg/
day for 5 days from cycle day 3. A control cycle (CC only cycle) woman will continue on CC
alone plus cervical irrigation of cervix with 1 ml of 0.9% normal saline at cycle day 8 and
10 to assure patient-blinded method. The study group, the same will be done plus the
intrauterine infusion of Autologous platelet-rich plasma (PRP) in 8th and 10th days of the
cycle. In both groups, the endometrial thickness and Power Doppler evaluation of their
endometrial and sub-endometrial blood flow will be measured on the day of Human Chorionic
Gonadotropin (HCG) administration.