Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Determine whether there is prompt engraftment after autologous peripheral
blood stem cell transplantation using filgrastim (G-CSF) mobilization in patients with life
threatening autoimmune diseases.
II. Determine the kinetics of T- and B-cell immune reconstitution after a combination of
timed plasmapheresis, high dose cyclophosphamide and total lymphoid irradiation, and
posttransplant immunosuppression with cyclosporine in these patients.
III. Determine whether this treatment regimen beneficially influences the clinical course of
these patients.