Overview

Autoimmune Basis for Postural Tachycardia Syndrome

Status:
Enrolling by invitation
Trial end date:
2022-07-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to see if some people with postural tachycardia syndrome (POTS) have higher levels of immune proteins (autoantibodies) directed against receptors of the autonomic nervous system, and if these autoantibodies make a difference in their POTS symptoms. The investigators also want to see if the levels of these autoantibodies stay the same over time.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Vanderbilt University
Vanderbilt University Medical Center
Collaborator:
University of Oklahoma
Treatments:
Autoantibodies
Isoproterenol
Oxymetazoline
Phenylephrine
Criteria
Inclusion Criteria:

- 18-50 years old

- Postural Tachycardia Syndrome: Heart rate increase >30 bpm from supine within 10 min
of standing, in the absence of orthostatic hypotension (>20/10 mmHg fall in blood
pressure), with chronic symptoms (> 6 months), and in the absence of other acute cause
of orthostatic tachycardia.

- Able and willing to provide informed consent

- Female premenopausal subjects must utilize adequate birth control and willingness to
undergo serum beta-hCG testing

- The subject must understand and be able to comply with the study procedures and
restrictions.

Exclusion Criteria:

- Hypertension (>150 mmHg systolic and >100 mmHg diastolic) based on history or findings
at screening.

- Orthostatic hypotension (consistent drop in blood pressure >20/10 mmHg with 10 min
stand)

- Pregnancy

- Cardiovascular disease, such as myocardial infarction within 6 months, angina
pectoris, significant arrhythmia (sinus tachycardia is not excluded), deep vein
thrombosis, pulmonary embolism

- History of serious neurologic disease

- History or presence of significant immunological or hematological disorders

- Clinically significant gastrointestinal impairment that could interfere with dietary
compliance or drug absorption

- Impaired hepatic function (aspartate amino transaminase and/or alanine amino
transaminase >1.5 x upper limit of normal range)

- Impaired renal function (serum creatinine >1.5 mg/dL)

- Hematocrit <28%

- Current or concurrent disease that could affect the absorption, action or disposition
of the drug, or clinical or laboratory assessments.

- Any underlying or acute disease requiring regular medication that could possibly pose
a threat to the subject or make implementation of the protocol or interpretation of
the study results difficult

- Inability to comply with the protocol

Healthy control subjects will be healthy, non-smoking and on no chronic medications at the
time of the study. Healthy control subjects will be group-matched to the POTS patients for
age and gender. We will attempt to study female patients in the first half of their
menstrual cycle to minimize cyclical variability.