Augmenting Clozapine With Sertindole - SERCLOZ

• Status: Completed
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to determine whether addition of sertindole to clozapine treatment can improve psychosis or the metabolic side-effects of clozapine in patients with treatment-resistant schizophrenia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Collaborator: H. Lundbeck A/S
• Treatments: Clozapine; Sertindole

Criteria

Inclusion Criteria:

• ICD10 diagnosis of schizophrenia (F20.0-3)

• Clozapine treatment minimum 6 months

• Total PANSS >65

• No antipsychotic other than clozapine drug 1 month prior inclusion

Exclusion Criteria:

• QTc >500 ms

• Violence to SPC of clozapine or Serdolect

• Major depression

• Significant substance misuse interfering with participating in the study

• Cardiovascular disease