Atorvastatin in Patients With Ulcerative Colitis

• Status: Not yet recruiting
• Trial end date: 2027-06-20
• Target enrollment: 0
• Participant gender: All

Summary

Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa; however, the exact underlying mechanisms of UC remain poorly understood. Statins exert numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement, and immunomodulation independent of their basic lipid-lowering property.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Atorvastatin

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• Both male and female will be included

• Negative pregnancy test and effective contraception

Exclusion Criteria:

• Breastfeeding

• Significant liver and kidney function abnormalities

• Colorectal cancer patients

• Patients with severe UC

• Patients taking rectal or systemic steroids

• Patients taking immunosuppressives or biological therapies