Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE)
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is:
1. To assess the efficacy of a lipid-lowering agent (atorvastatin) on the development of
atherosclerosis that predisposes children with SLE to cardiovascular events in
adulthood.
2. To assess the safety of intermediate-term (36 months) treatment of children and young
adults with atorvastatin.
3. To further characterize the course of SLE in children and young adults, by establishing
a cohort of pediatric SLE patients to be followed prospectively.
4. To establish a mechanism for conducting clinical trials in rare pediatric rheumatic
diseases using the Children's Arthritis and Rheumatology Research Alliance (CARRA).