The coronavirus disease-2019 (COVID-19) is spreading throughout the United States. While
there are no known therapies to treat those who have become sick, there have been some
reports that a medication currently used to treat rheumatoid arthritis, lupus, and malaria
(Hydroxychloroquine sulfate, also known as Plaquenil) may help to lessen the chance or
severity of illness, especially if combined with a medicine that treats other kinds of
infections (Azithromycin, also known as Zithromax or Zmax or Zpak).
There are some people who test positive for the virus but who are otherwise not ill. Current
standard of care is to advise these people to self-monitor but no treatment is offered. It is
not known how many of these individuals will remain symptom free, and how many will become
sick or how severe those symptoms will be. This study will randomize those people who do not
have symptoms into one of three treatment plans 1) Hydroxycholoquine and Azithromycin, or 2)
no active medication (placebo). All participants will be followed for 2 months.
The study will determine if there is any benefit to those who are asymptomatic to taking
taking Hydroxychloroquine sulfate in combination with Azithromycin, or if there is no benefit
from taking these medications.