Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
Status:
Unknown status
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
The goal of this research program is to understand the natural history of asymptomatic
bacteriuria in the renal transplant patients, to determine if screening for asymptomatic
bacteriuria and identification of key host characteristics and virulence factors present on
uropathogenic bacteria identifies a sub-population of patients with asymptomatic bacteriuria
that are at risk to develop symptomatic urinary tract infection. Ultimately, the knowledge
obtained from this study will prevent inappropriate antibiotic use and may identify whether
certain bacterial isolates predispose to renal allograft injury. We will test the hypothesis
that (i) asymptomatic bacteriuria is common in the renal allograft recipient and (ii) that
symptomatic urinary tract infection and renal allograft dysfunction do not occur unless key
host susceptibility factors and uropathogenic bacterial virulence factors are present.