Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
Astragalus membranaceus (AM) is used to treat stroke for a long period, and a number of
studies have known that AM can reduce cerebral infarction area and has anti-oxidation.
Hemorrhagic stroke will induce secondary peri-blood clot edema and that may increase
intracranial pressure to exacerbate clinical symptom. Therefore, the purpose of the present
study was to investigate the effect of AM on hemorrhagic stroke edema. The investigators
selected 80 hemorrhagic stroke patients , and who the stroke is first attack, they were
randomly divided into control and experimental groups, and each group was 40 patients as
follows: 1) control group, accepted AM placebo 2.8 g three times per day (tid) treatment for
continuously 14 days from second day of admission or operation, except standard ordinary
treatment; 2) experimental group, accepted AM 2.8 g tid treatment for continuously 14 days
from second day of admission or operation, except standard ordinary treatment. Computer
tomography (CT) examination was done at first day, 4th day and 7th day of admission,
respectively. The ratio of brain edema was calculated by CT image, and inflammatory index
including the levels of C-reactive protein (CRP), erythrocyte sedimentation rate
(ESR)，Creatine Kinase BB Isoenzyme (CMBB). D-dimer from venous blood also were measured. In
addition, the score including Glasgow outcome scale (GOS), Modified rankin scale (MRS),
Function independence measure (FIM), Barthel index (BI) was recorded one week, four weeks and
12 weeks after admission or surgical operation, as an index for clinical symptoms. The index
for the therapeutic effect of AM was according to above-mentioned the ratio of brain edema,
inflammatory index and clinical symptoms.
The investigators expected the results of the present study may provide a scientific evidence
for the hemorrhagic stroke edema treatment of AM, thus, the present study may contribute to
use the method of integrated Chinese and Western Medicine for the treatment of stroke, and to
the research of Chinese Medicine.