Association Between Body Size and Response to Hydromorphone in ED

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Pain is the most common complaint for patients presenting to the emergency department (ED). Inadequate pain relief is also a common problem in ED. Patients' pain perceptions and responses to intravenous opioids vary widely and are influenced by multiple factors. The objective of the current study is to examine the association between total body weight, BMI (body mass index) and clinical response to a fixed dose of intravenous hydromorphone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Albert Einstein College of Medicine; Jacobi Medical Center
• Treatments: Hydromorphone

Criteria

Inclusion Criteria:

• English or Spanish speaking

• Age 18 - 65 years old

• Acute pain (less than 7 days in duration)

• Pain with sufficient severity to warrant use of intravenous opioids in the judgment of ED attending physician

Exclusion Criteria:

• Allergy to hydromorphone

• Systolic blood pressure < 90 mm Hg

• Room air oxygen saturation by pulse oximetry < 95% at baseline without supplemental oxygen

• Alcohol or other drug intoxication as judged by the attending physician

• Suspicion of drug seeking by ED physician

• Use of opioids within the past 24 hours

• Use of a monoamine oxidase inhibitor

• Concurrent use of benzodiazepines

• Presence of a chronic pain syndrome (such as sickle cell disease, peripheral neuropathy, diabetic neuropathy, or fibromyalgia)

• History of COPD, sleep apnea, renal failure, liver disease

• Pregnancy or breast feeding

• Prior entry of patient in the study

• Inability or unwillingness to provide informed consent