Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

• Status: Completed
• Trial end date: 2010-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck. Following this type of surgery, patients often need medication to maintain their blood pressure in the intensive care unit. The effect of these drugs on the transplanted tissues is unknown. This study investigates the effects of four commonly used drugs on free flap perfusion.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oxford University Hospitals NHS Trust
• Treatments: Dobutamine; Dopexamine; Epinephrine; Epinephryl borate; Norepinephrine; Racepinephrine

Criteria

Inclusion Criteria:

• Patients undergoing free tissue transfer surgery at the John Radcliffe Hospital wih planned post-operative admission to the intensive care unit.

Exclusion Criteria:

• Pregnancy

• Weight >100kg

• Contraindications to pressor infusions

• Overnight ventilation not indicated