Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline
Status:
Recruiting
Trial end date:
2023-09-25
Target enrollment:
Participant gender:
Summary
Adults with known respiratory allergy/asthma with known skin test sensitization will undergo
repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms).
Each site will be challenged with up to three known allergens, saline and histamine controls.
Mean wheal diameter after 20 minutes challenge will be determined. This is followed by
placement of minocycline cream (0%, 1%, 2%, 3%), placed in randomized fashion at each of 1 of
4 skin test sites. Measurement of subsequent wheal diameter will be done at 30 minutes, 60
minutes and 24 hours.
Phase:
Phase 2
Details
Lead Sponsor:
State University of New York - Downstate Medical Center