Assessment of Peripheral GABA Receptors for Local Pain Relief

• Status: Unknown status
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The effect of peripheral GABAA receptor activation on pain and sensitivity in healthy human subjects has never been investigated. However, as earlier studies suggest that activation of peripheral GABAA receptors is anti-nociceptive in rats, it is important to determine if these findings can be translated into human subjects to determine if peripheral GABAA receptors are a viable target for future analgesic drug development.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aalborg University
• Treatments: Butyric Acid; Capsaicin; gamma-Aminobutyric Acid; Lidocaine; Lorazepam; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Aged 20-40 years

• Free from ongoing or chronic pain

• Adequate conversational English

Exclusion Criteria:

• Pregnancy or intent to become pregnant, breast feeding

• Signs or symptoms of any serious systemic diseases

• Current malignancies

• High blood pressure

• Requirement for chronic administration of psychiatric, analgesic or other medications that might influence their response to pain

• Frequent recreational drug or alcohol use

• Previous neurologic, musculoskeletal or mental illnesses

• Lack of ability to cooperate