Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
The objective of this application is to identify a pharmacologic agent which helps couples in
whom the female partner ovulates regularly successfully obtain their goal of delivering a
healthy child, whose use will result in low rates of multiple gestations. The central
hypothesis is that, in infertile ovulatory women undergoing ovarian stimulation (OS) and
intrauterine insemination (IUI), the use of aromatase inhibitors (AI) will stimulate the
ovaries sufficiently to produce no reduction in the rate of pregnancy, while significantly
reducing the numbers of multiple gestational pregnancies that result from stimulation with
clomiphene citrate (CC) or follicle stimulating hormone (FSH). The rationale for the proposed
research is that reduction of multiple pregnancy rates could significantly reduce maternal
and neonatal morbidity and mortality, as well as the cost of healthcare for these individuals
and society.
Phase:
Phase 3
Details
Lead Sponsor:
Yale University
Collaborators:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Penn State University University of Colorado, Denver University of Michigan University of Pennsylvania University of Texas University of Vermont Wayne State University