Overview

Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

Status:
RECRUITING

Trial end date:
2029-11-30

Target enrollment:

Participant gender:

Summary

This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of injection drug use, with or without HIV. Participants will receive metformin or placebo and undergo immune system assessments, including vaccine response evaluations.

Phase:

PHASE4

Details

Lead Sponsor:

University of Alabama at Birmingham

Collaborator:

National Institute on Drug Abuse (NIDA)

Treatments:

Metformin
smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic