Specific Aim: To determine whether neutrophils, active elastase, and cytokines measured in
sputum induced using hypertonic saline are useful screening tests for determining if a
particular agent with known anti-inflammatory properties is a suitable candidate for more
extensive clinical trials in patients with CF. This aim will be addressed using an
anti-inflammatory agent, ibuprofen, that has been shown to have clinical benefit in CF. A "no
treatment" arm will be included as the control group.
Phase:
N/A
Details
Lead Sponsor:
Ramsey, Bonnie, MD
Collaborators:
Cystic Fibrosis Foundation Cystic Fibrosis Foundation Therapeutics